European Congress of Psychiatry presents meta-analysis on the benefits of CBD in autism

A meta-analysis presented in European Congress of Psychiatry, in 2025, suggests that the administration of CBD (cannabidiol) therapy may lead to significant beneficial effects on the social behavior of children with autism, as well as in the reduction of disruptive behaviors in children and adolescents diagnosed with this disorder. 

The extensive systematic review synthesized data from three randomized, placebo-controlled trials involving 276 participants aged 5 to 21 years, with a mean age of 10.5 years. Each study evaluated the efficacy and safety of cannabis extracts containing CBD in treating symptoms of autism. Initial doses were 1 mg/kg per day, progressively increased to 10 mg/kg per day, depending on patient tolerance.

The review presented the following conclusions:

• Improved social responsiveness: Participants who received CBD showed moderate but significant improvements in social interaction skills.
• Reducing disruptive behavior: Studies have recorded statistically significant reductions in behaviors such as aggression, hyperactivity and irritability.
• Anxiety Relief: CBD has been shown to reduce anxiety levels, a common problem among individuals with ASD.
• Improved sleep quality: Although the improvements in sleep were not statistically significant, the trend was positive.
• Security profile: CBD therapy was well tolerated. The incidence of adverse events was comparable to that in the placebo group.

The results suggest that CBD has considerable potential as a complementary treatment for ASD, particularly in the management of behavioral and emotional symptoms.

What is Autism and how can you benefit from CBD?

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder that affects approximately 1 in 100 children worldwide. Characterized by difficulties with communication, emotional expression, and repetitive behaviors, ASD often poses significant challenges for affected individuals and their families. Although several treatment strategies exist, many have offered limited success. Current emerging research highlights cannabidiol (CBD), a non-psychoactive compound derived from cannabis, as a potential alternative therapy that may help reduce the core symptoms of ASD.

Cannabidiol (CBD) is one of the many chemical compounds found in the cannabis plant. Unlike tetrahydrocannabinol (THC), CBD does not induce psychoactive effects. Instead, it interacts with the endocannabinoid system, which plays a key role in regulating mood, behavior, and neurological development. This interaction has prompted scientists to explore the potential of CBD in managing various neurological and psychiatric conditions, including ASD.

Conventional treatments for Autism Spectrum Disorders (ASD) typically include behavioral therapies, antipsychotics, and antidepressants. However, it is important to note that such interventions may not be effective for all individuals and may lead to undesirable side effects. In contrast, CBD presents a non-invasive and well-tolerated alternative that addresses multiple symptoms simultaneously.

What sets CBD apart is its broad spectrum of therapeutic action. By acting on inflammation, anxiety, sleep regulation and neurochemical imbalances, CBD may help restore balance to the developing brains of children and adolescents with ASD.

Precautions and considerations: The need for larger trials

In line with the promising results obtained to date, the researchers highlight the imperative need for further research. With only three qualifying studies and a relatively small sample size, the limitations of the current evidence are evident. Larger, well-controlled trials are imperative to determine the optimal dosage, long-term safety and efficacy of CBD across different ASD subtypes.

Lara Cappelletti Beneti Branco, principal investigator at the São Camilo University Center and the University of São Paulo, said: “Although current treatments are often insufficient, this research highlights the therapeutic potential of CBD.” That said, it is necessary to remain cautious and continue to build a more solid foundation by conducting larger-scale trials.

Professor Geert Dom, President of the European Psychiatric Association, echoed this view, emphasising the pressing need for effective, evidence-based treatments to address the rise in ASD diagnoses globally.

What does this mean for families and doctors?

Integrating CBD into autism treatment plans could represent a game-changing shift in the way clinicians approach the management of ASD. For families facing behavioral challenges and limited treatment options, CBD may provide a viable, scientifically proven alternative.

However, it is imperative that parents consult with healthcare experts before beginning CBD therapy. Medical supervision ensures proper dosing, safety monitoring, and alignment with existing treatments.

A step forward in innovation in autism therapy

As the prevalence of autism continues to rise, so does the demand for innovative and effective treatments. The results of this meta-analysis provide a starting point for families and healthcare professionals to investigate new solutions.

CBD therapy, while not a cure, appears to provide real benefits in managing ASD symptoms, particularly in improving social skills and reducing disruptive behaviors. With a favorable safety profile and multi-symptom impact, CBD (cannabidiol) has the potential to become a cornerstone in personalized autism treatment. However, future research confirming its long-term efficacy and safety is essential for this possibility to be fully explored.

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João Xabregas

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With a professional background in CAD technical drawing (2D and 3D), João Xabregas is an activist and advocate for all uses and applications of cannabis. He discovered and entered the world of cannabis during his youth, where he developed a special interest in the cultivation of the plant, which led him on a journey of self-learning through the world of cannabis that continues to this day. His adventures linked to cannabis cultivation began with the same goal as many others: to be able to guarantee the quality and eliminate any possible risks to his health of what he consumed, as well as to avoid any type of dependence on the illicit market. However, he quickly began to view the world of cannabis and everything related to it with a very different perspective. He admits the enormous passion he has for the most persecuted plant in the world and about which he is always willing to write and have a good conversation.

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